Investigating Pathological Mechanisms in Non-alcoholic Fatty Liver Disease: Cross-sectional Comparative Study Between Patients and Healthy Controls
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY
To identify key characteristics of the tissue resident and peripherally circulating immune-phenotype in addition to blood markers, metabolic profile, faecal and oral microbiota in non-alcoholic fatty liver disease
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Age ≥18 years
• Confirmed non-alcoholic Fatty liver disease (diagnosed clinically, radiologically or histologically)
• If diabetic, Diagnosed with Type 2 Diabetes Mellitus
⁃ OR
⁃ • Healthy Control: no diagnosis of any liver condition including NAFLD
⁃ o NAFLD excluded by Fibroscan Controlled Attenuation Parameter (CAP) score of \<222 dB/m
Locations
Other Locations
United Kingdom
Homerton University Hospital Foundation Trust
RECRUITING
London
Contact Information
Primary
William Alazawi, MD Phd
w.alazawi@qmul.ac.uk
+442078822308
Backup
James Brindley, Md Phd
james.brindley@nhs.net
+442078827198
Time Frame
Start Date: 2019-03-05
Estimated Completion Date: 2026-04-01
Participants
Target number of participants: 153
Treatments
Healthy Control
non-obese individuals without fatty liver disease
Obese wihtout non-alcoholic steatohepatitis
Body mass index greater than 30 without liver histological evidence of non-alcoholic fatty liver disease
Obese Non-alcoholic steatohepatitis
Body mass index greater than 30 with liver histological evidence of non-alcoholic fatty liver disease
Related Therapeutic Areas
Sponsors
Collaborators: King's College Hospital NHS Trust, Barts & The London NHS Trust, Homerton University Hospital NHS Foundation Trust
Leads: Queen Mary University of London